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脯氨酸羟化酶P4HA1介导核孤儿受体NR4A1琥珀酰化促进主动脉瓣钙化的机制研究

P4HA1-Mediated Succinylation of Orphan Nuclear Receptor NR4A1 Promotes Aortic Valve Calcification

PEN2通过稳定SLC25A51介导线粒体与细胞核间NAD⁺再分布抑制动脉钙化

PEN2 Stabilizes SLC25A51 to Inhibit Arterial Calcification Through NAD+ redistribution Between Mitochondrion and Nucleus

单细胞与高清空间转录组学揭示主动脉瓣脱垂中分层结构崩塌及细胞间通讯

Single-cell and High-Definition Spatial Transcriptomics Uncover the Collapse of Layered Architecture and Cellular Crosstalk in Aortic Valve Prolapse

黄芪甲苷IV通过抑制CCL2/NF-κB信号通路改善LPS诱导的大鼠心肌重塑及功能障碍

Astragaloside IV Ameliorates LPS-Induced Myocardial Remodeling and Dysfunction in Rats by Inhibiting the CCL2/NF-κB Signaling Pathway

CHK1通过抑制AHSA1泛素化激活线粒体自噬减轻心脏衰老

CHK1 Activates Mitophagy to Attenuate Cardiac Senescence via Inhibiting AHSA1-Ubiquitination

三尖瓣关闭不全患者循环血miRNA表达差异

Differential Expression of Circulating miRNAs in Patients with Tricuspid Regurgitation

UBC9介导的SUMO化修饰通过调控VSMCs中Ryr2依赖性钙稳态减轻血管钙化

UBC9-mediated SUMOylation Attenuates Vascular Calcification by Regulating Ryr2-Dependent Calcium Homeostasis in VSMCs

E3泛素连接酶在钙化性主动脉瓣疾病发生发展的作用

The Role of E3 Ubiquitin Ligases in the Pathogenesis and Progression of Calcific Aortic Valve Disease

CD34+ 瓣膜间质祖细胞通过PDGFR-JNK-JunB信号轴促进老年退行性主动脉瓣膜硬化

CD34+ progenitor VICs Promote Aging-associated Aortic Valve Sclerosis Through PDGFR-JNK-JunB axis

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